Introduction
Microbial aerosol biological, physical and chemical properties have a very important impact on respiratory infections.
aerosol The biological properties of the aerosol contains itself, that is, microorganism infection and virulence is a decisive factor in the consequence of respiratory infection. Different kinds of microbial aerosols in different strains can reach several quantities under similar conditions.
Sepaled from 4 of the 4th Burguna of Ditrrickburg, four different colonies type strains, which have no significant difference in mouse skin infection but respiratory tract in guinea pigs and mice. Intermediate roughness (Sr1.RSN) The monopolysis is much smaller than roughness; at the same time, it also has a difference from the percentage of bacteria from spleen. Balaye.a (1975) shows that the ceram (e) rava injury Cold clocks can significantly improve the disease of respiratory infection after the mouse and guinea pigs, and after passing through chicken embryos Phenomenon.
The anthracnogene aerosol respiratory LD grown in different ingredient medium is different. When the medium contains manganese sulfate glucose, there is a strong pathogenic force in the respiratory tract.
It is worth noting that different times after aerosolization (referred to as aperture), the infectivity and pathogenic force are sometimes different. 33 min and 24H age of Trierturi aerosol guinea pigs inhaled half a monopolitidity (number of bacteria) were significantly affected by 1.37 min. Take the monkey as an example, inhalation LD, O is 36 bacteria, 120min is 2,394 seedlings 120min. The average germ 1.4m] n of Triel aerosol respiratory infection is not affected by bacterial culture time. However, when the genus is longer to 330rnin, the infection dose increases significantly when the culture time is long. It is currently known that the pathogenicity of the murine hyperobacillus aerosol is also affected by the collar.
Avolicin chemical properties
A variety of chemical components in aerosol particles sometimes affect the infectivity of the microbial aerosol and pathogenic force. Early Study of Young has shown that anthrax bacteria reduces the cadmium (CDCRO) respiratory LD in the liquid by 260 times, which reduces the mouse LD by 96 times, which is 9 times that of the guinea pig. The LD of the copper chloride respiratory tract is reduced by 102 times, and these metal salts can promote the slow glutathione (Glutath) to reduce the body naturally resistance. In addition, some surfactants can also increase the infectivity and pathogenic force of the anthraxercar aerosol respiratory tract, and 5% of Tergitor can reduce guinea pigs and mouse LD by 16 times. Studies have shown that such substances have a direct effect on the poor respiratory chamber, but it can promote the germination, breeding and spread of anthrax bacteria. Rhin found a strange but also illustrated different phenomena of infection mechanisms and other ways. When the ovals were added in the suspension of the anthrax bacteria, mice, guinea pigs, and rabbits were reduced by 52 times higher than the subject, but the respiratory LD. It is significantly increased. Egg yolk acts as foreign matter in the respiratory tract to phagochemocalasion of bacteria in the respiratory tract, and reduces the growth of cells with bacteria.
Avolic physical properties
research demonstrates the physical properties of aerosol, such as dosage, particle shape, density, temperature, moisture absorbing, electrical and diameter of the inhalation particles The calibration, distribution and retention in the respiratory tract have a certain degree. Thus, these factors must have an impact on the infectivity of the microbial aerosol.
Particle size is one of the important factors affecting the infectivity of microbial aerosol, since the particle size and all aerosol particles (settling, impact, diffusion, condense, etc.) are very close relation. According to research, the host to microbial susceptibility and particle in the respiratory tract is an important factor in determining the respiratory LD, so the size of the particle size has an important impact on the results of microbial inhalation infection. All the US military's information on biological weapons was calculated on the concentration of 1 to 5 μm particle concentrations in the data of the biological weapon. When some microbial aerosol particles increase, the infectivity decreases, such as hemolytic bacteria, tuberculosis, Trialiobacillus, anthrax bacteria, Q-hot grade, the martious virus and adenovirus are here. Other microorganisms, such as mouth-to-mouth disease viruses, Copochi virus and nasal virus aerosol particles increased more than infectivity. There is also a small number of microorganisms, such as influenza aerosol infections to particle size requirements are unstrusted, and the viruses of the lower respiratory tract have strong appeal. In general, the bacterial toxin aerosol can be absorbed across the respiratory tract, but the small particles of the lung deep particles can be absorbed faster, and the pathogen is stronger. Of course, the large particle aerosol contains more microorganisms, which cannot be ignored. In recent years, some people have emphasized the role of large particles. It is believed that 20 μm large particles are conducive to the survival of microorganisms and is prone to damage, which is called a new view of the biological pond effort study.