classification
fibroblasts are the main cellular components of loose connective tissue, and cells have a shuttle or flat star shape, with protrusions. According to different functional activity, the cells are divided into fibroblasts and fibrous cells.
Fibroblasts are cells, cells and cell nuclear nucleus, clear contours, clear nucleation, and significant protein synthesis and secretion activities; in maturity Or fibroblasts, cells, and cells are smaller, and are unusually developed in a long shuttle, and the crude endoplasmic mesh and a gelglass complex are not developed, referred to as fibroblasts. Fiber cell function is not active, the cell profile is not obvious, the core is deep, the nucleol is not obvious, and the cells are less. Under the stimulation of factors such as trauma, some fibrous cells can be re-converted into naive fibroblasts, and their functional activities are also restored, and they are involved in the repair of tissue injury.
Fibroblasts Participate in collagen fibers
fibroblasts, such as proline and lysine, etc. The synthesis of the pre-synthesis of the pre-alpha polypeptide chain, and the polypeptide chain is delivered to the Golgi complex, and the prodelant molecule is formed. Preconduron was brought to the cell surface by secreting vesicles and then released through the cytotype. Under the catalysis of the front collaborate, the tail segment of each predecessor polypeptide chain was removed, and the original molecule was formed. Many raw plastic molecules are arranged in parallel, combined into collagen fibers having periodic horizontal ribs. Collagen fibers are combined with each other by collagen.
Fibroblasts and connective tissue
fibroblasts are the most common cells in connective tissue, and are differentiated from mesenchymal cells during embryonic. In connective tissue, fibroblasts are also present in their mature state-fibrous cells (fiber cells), both of which can be transformed with each other under certain conditions. Different types of connective tissues are different from the number of fibroblasts. Typically, the number of fibroblasts in the loose connective tissue is less than the number of fibroblasts contained in the same volume, so that the culture into fibroblasts are separated by dense tissue such as leather.
Secrecy cells and proteins secreted and synthesized
into fibroblast morphology, common spindle, mostly angle and flat star, its form can still be dependent according to cells The function changes and the physical properties at its attachment have changed. The fibroblast cells are large, and the cytoplasmic basis, the nucleus is large, and the chromatography is shallow, and the nucleol is obvious. Under electron microscopy, its cytoplasm is visible to a rich rough endoplasmic network, free ribosomal and developed gelgi complex indicating that it has the function of synthesizing and secreting proteins.
Fibroblasts in wound repair
Fibroblasts in general wound repair, various trauma, various trauma, can cause varying degrees of cell degeneration, necrotizing and tissue defects. Tissue repair must be performed by the formation of cellular proliferation and intercellular matrix. Fibroblasts play a very important role during this repair. Taking the wound healing process as an example, fibroblasts are proliferated by mitosis, from 4 to 5 days or 6 days to synthesize and secrete a large amount of collagen fiber and matrix ingredients, forming granulation tissue, filled the wound tissue defect. Creating conditions for the cover of epidermal cells. In wound healing, fibroblasts are mainly derived from topical fibroblasts and unlibained mesenchymal cells of the dermal papillary layer, as well as fibroblasts and week cells around the blood vessel. When visceral injury, the fibroblasts involved in the repair process are multi-originate and envelopes, as well as connective tissues under the mucosa or under the submersible. Some people believe that a large amount of fibroblasts gathered in the injury healing process, on the one hand, the fibroblasts are proliferated by fracturing, and on the other hand, more is more than adjacent mesenchymal cells, fibroblasts and capillary peripheral cells. Evolution or swim to the injury. In the later stage of trauma repair, fibroblasts were involved in the reconstruction of post-repair tissue by secreting collagenase. Under certain pathological conditions, the granulation tissue or hyperplasia tissue blocks in fibroblasts as the main cellular component can also be calcified in non-bone tissue, causing ectopic ossification. However, for the participation cells and their mechanisms of ectopic bone, it is possible to develop cells such as mesenchymal cells, fibroblasts, endothelial cells, and capillary cyms, etc.. Participate in this process.