Pirrolidina

Descriptio chemica

Chemical : c ₁₂ h ₂₁ n ₃ > O ₃

system named : n6 - {[(2R, 3R) -3-methyl-3,4-dihydro-2h-pyrrol -2-yl] carbonyl} -l-lysine

Acido N6 - [(2R, 3R) -3-metil-3,4-diidro-2-idrozpirrolo-2-formil] L-lamina

: PYL O

: PYL O

Processus Inventionis

8 researchers from two research teams from Ohio State University identify the world's 22nd natural amino acid-pyrolily alleysine (Pyrrolysine) encoded by genetic genes. Since 1995, the Krzycki Study Group has found an unexpected phenomenon in the study of methyl methane (MMA, DMA, TMA) methyltransferase gene: there is a box of ingredients in the gene. Take a codon a UAG. Under normal circumstances, the codon should issue a signal to stop the protein synthesis, but there is no synthesis of the protein in the gene. The Krzycki Study Group was studied by mass spectrometry and EDMAN degradation, indicating that the codon encodes a modified lysine. The research team led by Chan and HAO was studied by the MTMB crystal structure of MTMB crystal structure in methane bacteria ( Methanosarcina Barkeri ), found that the amino acid residue encoded by codon UAG The density is different from the amino acid residue encoded by other 21 codon, which is linked (4R, 5R) 4-pyrrolin, a carboxyl group (4R, 5R) 4-pyrrolin. So they said this newly discovered amino acid is L-pyrrolidine.

Biologica actio

Pyrrolidine inventa in methane methylamine methyltransferase, amino acidum synthesin biologicae intermediae interesse notum est, cum vexillum amino acidum differat et formatur per determinationem codon UAG determinantis. E contra, synthetasis specificae pyrrolidyl-tRNA (PYLRS) et pyrrolidine TRNA (TRNA (superscript PYL)) diversa sunt etiam ab classic TRNA. Formatio bacilli methani producit pyrrolidyl-tRNA (PYL-TRNA (PYL)) per semitam directam et indirectam (PYL-TRNA (PYL superscript)), quae etiam per peculiarem structuram in mRNA et aliis regularibus mechanismus moderatur. UAG descriptam terminat codon vel pyrrolidine.