Characterintroduction
ZengBangzhe(alsoknownasZengJie)
"SystemsBiologyScienceThedevelopmentofengineeringandengineeringhasswepttheworldandwillbringnotonlyarevolutioninbiomedicine;moreover,itwillbearevolutioninthemanufacturingindustry-thethirdindustrialrevolution."---ZengBangzhe(July2007)
Name:ZengJie(ZengJie),word:Bangzhe(Bangzhe,orBenjoeTseng),theancestralhomeofJiangxiJi’an,heisthedescendantofZengZiandWuZixu,July17,1963(Mayinthelunarcalendar)27th)BorninGutaiMountain,Loudi,Hunan,grandmotherWu'sfamilywasborninHuangpuMilitaryAcademy.
Thefirstinternationallypublishedconceptsandprinciplesofsystemsgenetics(1994),systemsmedicine(1992)andsystemsbioengineering(1994),andthefirstinternationalconceptandmethodoffallopiantubebioreactor(1994),cellTheconceptandmodelofcomputer(1999-2002),thefirstinternationalestablishmentoftheSystemBiologyScienceandEngineeringNetwork(1999)andtheintroductionofstructuraltheory(1986)-thebasisofpan-evolutiontheory.
Biographicallife
1985
GraduatedfromtheDepartmentofBiology,XiamenUniversityinJuly,majoringinanimalcytogenetics,whileincollegeThesis:Ontheecologicaladaptationofanimalsenseorgans,onthestructure,functionandevolutionoforganisms,andthechromosomekaryotypeanalysisofJindingDuck.
1985-1994
TaughtinagronomyandmedicalschoolsinHunanProvince.Hewrotein1986andpublished"StructuralTheory-Pan"TheoryofEvolution"expoundsthestructurallogicofsystemphilosophy,systemscience,andtheexperimentandsystemmethodologythattheintersectionofChineseandWesternculturesinfluencemodernscience,andproposessystem(structural)geneticsandsystemmedicine,systembiologyConceptofengineering.
1994-1997
WorkedattheInstituteofMicrobiology,ChineseAcademyofSciences,andproposedtheconceptoftransgenicpoultryoviductbioreactor,andadoptedovalbuminThegeneflankingsequenceconstructsavectorplanforexpressingforeignproteins(goldeggplan).In1996,hehostedthe1stInternationalSymposiumonGeneticallyModifiedAnimals(Secretary-General),andbecameaneditorialboardmemberofthe"BiotechnologyBulletin"andalifememberoftheChineseSocietyofBioengineering.
1997-2006
FullyfundedtoworkinuniversitiesandresearchcentersinIsrael(TelAviv),Germany(FAL),andtheUnitedKingdom(Birmingham)Doctoralresearch,researchscientistandresearcher,andpresidedover(grant-holder)SPARKSFoundationfunding,trainingseveralinternationalgraduatestudents.StudiedattheAmericanAcademyofSciencesJohnR.Roth,thesubjectinvolvesmulti-generegulationofarteriosclerosis,lipidmetabolism,pituitaryendocrinecelldevelopmentsignaltransductionandtranscriptionfactorgeneregulation,andhereditarymuscleatrophycellapoptosissignaltransductionandgeneregulationAnddrugscreening,usingRNAitransgenictechnology,stemcellinvitrodifferentiationandhigh-throughputhormoneproteinanalysis,cDNAchiptechnologyandotherbiotechnologies,constructanewexpressionvector,clone2newgenes(NIHgenebank),andestablishlovastatin-resistantCHOMutationsinnewcelllines,etc.In1999,thegenbrainbiosystemnetworkwasestablishedandtheWorldFederationofSystemsBiosystemsandEngineering(WABSE)wasestablished.
2008
InApril,theBenjoeInstituteofSystemBioengineeringwasestablished,andthesyntheticbiotechnologyplatform-SystemGeneticsLaboratorywasestablished.BangzheSystemBiologicalEngineeringCo.,Ltd.isheadingforthedevelopmentroadofscientificresearchandindustrialeconomy.
He(penname,YuLuo·Hongye)alsohasmanyworksonappearancepainting,phantompoetryandphilosophy,andresearchonthehistoryofscience,fromTaoist-structuraltheory,Confucian-socialtheory,Zen-Spiritualism,Mohist-practicaltheory,discussingthedialogueandintegrationbetweenChineseandWesternphilosophyandculture.
Academicthought
1)Greek,Jewish(Persianperiod),Indian,andChineseclassicculturalmodels(1991)constitutethebasicelementsofhumancivilization.TheQufu,Wudang,Wutai,andHuizhoumodelsofChinesecivilizationconstitutedthebasicculturalpattern.DuringtheMingandQingDynasties,industriesandcommercesuchastextilesandminingsprouted.Theelementsofscienceandcultureandtheprototypesoftechnologicalinventionswerebasicallyformed.
2)Structuralmodelconversion,ItalianRenaissance,GermanReformation,FrenchHumanism,Britishscientificexploration,moderntechnologyandindustrialrevolution,andenteredtheglobalcivilizationofNorthAmerica,Australia,theEuropeanUnion,andEastAsia.
3)China’scoastalprovinces,Guangdong-Fujian,Jiangsu-Zhejiang,Hebei-Shandonganditssurroundings,radiatefromtheYangtzeandYellowRiverbasinstotheinland,formingamodernindustrializedurbanagglomerationsub-culturalsystem(1992-1994),FromXi’an,Wuhan,TaipeitoJapanandthePhilippines,formingageopoliticalpatternfacingthePacificOcean.
4)TheintegrationofChineseandWesterncultures,Mohistpracticalskillsandexperimentalmethods,Confuciansocialethicsandmoralnorms,Taoiststructuralmodelsandsystemlogic,Zencontemplationandconceptualclarification,etc.,gavebirthtoexperiments,Systemsciencemethodology.
5)ComprehensiveanalysisofChinesephilosophy,Westernphilosophyandsystemsciencetheories,expoundingthestructurallogicofthesystem,andthepan-evolutionarytheoryfrombiologicalevolutiontobiologicalsystemevolutionandartificialevolution.
6)TraditionalChineseandWesternmedicinewillmergeintosystemmedicineinthe21stcentury(1992-1995).Themeridiansystemisthefunctionalintegrationofneuro-endocrineandimmunesystems.Neuro-endocrineandgeneregulationconstituteanimals,Thetwo-wayregulationofhumandevelopment,thefour-colortheoremisequivalenttothetetrahedron,thefive-elementdiagramisequivalenttothetopologicalstructureofdiamond,andthefive-organismdiagramisasteady-statemodelofmaterialandenergymetabolism.
7)The21stcenturyistheeraofsystemsbiologicalscienceandengineering.Theintegrationofgeneticengineeringandbionicengineering,lifescienceandcomputersciencewillformthebiological(psychological)-physicsofsystemsbiologicalengineering(1994)Chemical)allianceindustrymodel.
8)Classicalgeneticsandmoleculargeneticswilldevelopintosystem(structure-schematic)genetics(1994),cellsignaltransduction,geneexpressionregulationandcellregeneration,differentiation,apoptosis,migration,Non-lineardynamicsofbondedcells,cellmappositioningandbiologicalmorphogenesis,multi-geneinteractiongenotype-phenotypecomplexbiologicalsystemresearch.
9)Researchanddevelopmentoftransgenicpoultryeggexpressionsystem,usingtheflankingsequenceoftheovalbumingenetoconstructanexpressionvector,publishingtheconceptofoviductbioreactor(1994)andtheexpressionoftransgenicpoultryeggswithmodifiedeggyolkgenesandeggshellgenesSystematicsolution.
10)Usingtheprinciplesofcellsignaltransduction,geneexpressionregulationandcellcommunicationtodesigngeneclusters,proteinmolecularmodulesandenergyconversionorganelles,aswellascellcomputermodelsforsignaltransmissionandbehaviorfeedbackbetweencells(2002).
11)Thedevelopmentofcelllineage,pathologicalcelllinegenedifferentialexpressionanalysisandgenecloningsequencefragmentmarkerdisplay(STFD)technologydevelopment(2003-2008),aswellascellsignaltransduction,generegulationandscreeningofnaturaldrugmoleculesThedevelopmentofmicrofluidicchiptechnology.
12)Followingtheindustrialrevolutionofmachineryandpowermachineryandtheindustrialrevolutionoftelecommunicationsandcomputers,thethirdindustrialrevolutionwillbetherevolutionofmedicineandbiologicalindustry.Chinahasestablishedaninnovation-orientedcountryandproposedthatthefocusofsupportfortechnologicalindustrializationshouldbeshiftedtothefieldoftechnologicalrevolutionthatmayproducepillarenterprisesinthefuture.
Biographyoflife
WhampoaMilitaryAcademy
wasborn(July17)inGutaishan,Hunan-"Noah'sArk",Thechildhoodlifeofthecreekandthepeonygardenatanaltitudeofmorethanathousandmetersformedacuriosityaboutnatureandthebiologicalworld.GrandmaWu’sfatherfollowedFangDingyingtotheWhampoaMilitaryAcademy,andlaterdidbusinessinWuhan.GrandpawasaprintingtechnologyexpertinHubei,Hunan,andbroughthismotherandunclebacktoHunanduringtheAnti-JapaneseWar.Telescopesandkaleidoscopeshaveaffectedtheinterestinscienceandinventioninchildhood.Beforeschoolage,Iusedtotakeapartthealarmclockandpartsathomealonetoseewhathappened.Inthesecondgradeofelementaryschool,theexquisitehardcovermedicalbooksinthemother'sbookstorebecamescientificenlightenmentbooks.FromjuniorhighschooltotheeraoftheInternettechnologyrevolution,Idevelopedahabitofreadingbooksinthelibrary.In1978,theNationalScienceConferencewasheld.TheSoviettranslationof"InterestingPhysics"andGaimov's"AAdventureinthePhysicalWorld"broughtintotheworldofthephysicalrevolution.Atthattime,alargenumberofbiographiesofscientists,inventorsandentrepreneurswerepublished.WorldScienceTheimpactoftheindustrialrevolutionhasinspiredagenerationofyoungpeopletostriveforgoals.
Entersystemscienceandphilosophicalresearch
Inmyyouth,hepursuedEinstein’stheoryofrelativity,theoreticalphysicsandunifiedscientificideas,andexploredthebrainandnervoussystem.Themechanism,andtheexcitementofphysicistsandchemiststurningtobiologicalresearch,Schrödingerwrote"Whatislife?""ThePhysicsViewofLivingCells",thebiologyteachermentionedtheincentivesofphotosynthesisandthebionicfactory.Asthebeststudentsinmiddleschoolmathematicsandphysics,theyfinallysteppedintothedoorofbiology."TheCollectedWorksofEinstein","HistoryofExperimentalPsychology"byPauline,and"BodyandWisdom"byCannonhaveprofoundlyinfluencedthethinkingoftheuniversityera.ChinesescientistsandphilosophersexploredwhymodernscienceandindustrialrevolutiondidnotoccurintheMingDynasty.InthenascentChinaofQingindustryandcommerce,afamousproblemofsciencehistorianJosephNeedhamarousedastrongdesiretoexplore.Fromextensiveresearchinphysics,chemistry,biology,psychology,andsociology,Idiscoveredthatstructure,function,andevolutionmaybemorefundamentalthantheconceptsoftime,space,andmotion.ItalsogaverisetotheideaofConfuciustravelingaroundtheworld.Attherighttime,IreadPiaget’s"Structuralism"anditsthinkingcoincidence,OwenLaszlo’s"Systems,StructuresandExperiences"wastranslatedandpublished,andBetalangfield’s"GeneralSystemTheory:Basics,DevelopmentandApplications""WasalsotranslatedandpublishedbyTsinghuaUniversity,andfinallyenteredthesystemscienceandphilosophyresearchconsciously.
Theexplorationofsocialsciences
Thepictureofthescientificworldinthe20thcentury,therevolutioninphysics,andthemovementofunifyingsciencehavealsoinfluencedsystemsscience.Philippine'sgeneralsystemtheorywasborninthisinternationalscientificbackground.Thepredictabilityofmathematicalphysics,equations,andtheidealofunifyingphysicsandbiologyarepursuedbymanyfamousscientists.ThestudyofisomorphismbetweentheoreticalbiophysicsandtransversalscienceisexactlyBertalanfe’sthought,expoundingtheapplicationofsystemtheorytobiologicalresearch.,Especiallytoexplaintheembryonicdevelopmentoforganismsandthegestalt,schemaoremergenceinpsychology.Afterin-depthexplorationofthetheoryofevolution,Chinesemedicinetheoryandcybernetics,systemtheory,etc.,theresearchdirectionwasdetermined.BecauseoftheinfluenceoftheunifiedscientifictheoryofEinsteinandBertalanfi,heenteredtheexplorationofsocialsciences.
StructureofScienceandtheFutureofChina
In1991,hepublishedamonographon"StructureofScienceandtheFutureofChina"inNatureInformation,proposinghumanityThefourclassicalmodelsofculture,Greek,Jewish(Persianperiod),ChinaandIndia,theintersectionofChineseandWesternculturesformatwo-dimensionalscienceofexperimentandsystematicmethods.From1992to1993,alongtheBeijing-Guangzhouline(Tianjin,Guangzhou,Taiyuan,Changsha,Xinxiang,Wuhan)participatedininternationalanddomesticacademicconferencesinthefieldsofChinesephilosophyofscience,dialecticsofnature,andbiomedicine,expoundingtherelationshipbetweenthestructure,functionandevolutionofthesystem,Aswellasconceptsandviewpointsfromthetheoryofbiologicalevolution,informationcontrolsystemstheorytothestructuraltheoryofpan-evolutionarysystems,systemsmedicineandsystemsbioengineering.InOctober1992,IparticipatedintheNationalConferenceonSystemScienceMethodsandEconomicSystemManagementheldinTaiyuan,Shanxi.Afterthat,Ifinallypositionedanddefinedtheresearchfieldasbiologicalsystemsandsystemstability,structuralmodels,andshiftedfromadynamicmodeltoamorphologicalmodel,thusclarifyingIntotheresearchofsystemscienceandbiologicalscience,andtheexplorationofsystembiologicalscienceandengineering.
Transgenictechnology
In1994,attheInternationalConferenceofChineseDevelopmentalBiologistsattheInstituteofDevelopmentalBiologyoftheChineseAcademyofSciences,aspecificresearchmodelwasproposed.BiologicaldevelopmentandTheevolutionaryneuroendocrine-immunecellregulationandtherhythmicandsteady-stateinteractionmechanismbetweenthegeneregulationofproteinexpression,thatis,thecellsignaltransductionandgeneregulationnetwork,organformation,biologicalmorphogenesis,etc.Enteredintotheconceptandresearchofsystematicgenetics.Frominitiallybecomingaresponderandexpectingtobecomeaphilosopherofthescientificunifiedtheorymovement,heturnedtoabiologist'spositioninstudyingbiologicalsystems,sohecametotheBeijingInstituteofMicrobiology,ChineseAcademyofSciencestoengageinbiotechnologycomputer-aideddesignandgenes(andfullgenes)Researchonsynthesisandgeneticmodificationtechnology.
Internationalacademicexchangesanddebates
Communicatewithfamousinternationalscientistsfrom1995to2000,suchasnanochemists,geneticists,computerscientists,etc.Theresearchanddevelopmentofintegratedbiologicalsystemssuchassystemsscientificmethods,molecularbiotechnologyandbiologicalinformationtechnology,includingtransgenicpoultryoviductbioreactors,systemsbioengineering,biomolecularcomputersandbiologicalsystemsandartificialevolutionfrommolecules,cells,andorganstoecologicallevelsAndothertheories.From1997to2003,itwasdebatedwithbiologicalreductiontheory.Intheresearchofendothelialcellgeneregulationofarteriosclerosisdisease,thetranscriptionfactorsignaltransductionpathwayofpituitarycelldevelopment,andthemolecularpharmacologyofhereditarymuscularatrophycellapoptosis,weinsistedonmulti-generegulationandnon-Mendelianinheritancepatterns,multi-geneinteractionsandcomplexrhythmsofpathcrossing,anddiscussionswithcomputerscientistsonthequantificationofsignalconductionandsystemscienceviewpoints.
SystemsBiologyScienceandEngineeringNetwork
Organizedfromthe1stInternationalSeminaronGeneticallyModifiedAnimalsandInternationalAcademicAssociation(Secretary-General)in1996DuringtheestablishmentofthegenbrainbiosystemnetworkinGermanyin1999,itcarriedoutextensivecommunicationsandexchangeswithforeignscientistsinthefieldsofsystemscience,computerscience,nanotechnology,biomedicine,neuroscience,etc.,andadvocatedthetheoryofbiologicalsystems.Combinedresearchwithmolecularbiologyandcomputerscience.
From2000to2003,systemsbiologyscienceandengineeringrapidlyemergedintheworld,includingsystemsbiology,syntheticbiologyandsystemsmedicine,integratedgenetics,etc.toexplorebiologicalsystemsandartificialbiologicalsystemsatthecellularandmolecularlevelResearch,combinedresearchmethodsofexperimentalbiologyandcomputationalbiology,andbiologicalsystemtheory,etc.
Intheoverseascareerattheturnofthecentury,Israeliscientistshaveactivethinkingandquickoperations,Germanscientistshaverigorouslogicandsophisticatedtechniques,andBritishscientistshavemeticuloussemanticsandquickactions,etc.,thusobtainingthescientificresearchspiritandthinking.Theabilitytoorganize,experiment,andexpressclearly,examinestheoriginsofEuropeanRenaissanceandmodernscience,andthenorthernandsouthernendsoftheEuropeancontinentontheSilkRoad.Birmingham,UK,wasthebirthplaceoftheIndustrialRevolution,andChina’sMingandQingindustryandcommercesproutedinthesouthoftheYangtzeRiver.Thedevelopmentofsystemsbiologyandengineeringwasfullyemergingatthistime,soIdecidedtoreturntoChina:oneistoexploretraditionalChineseculture,andtheotheristopromotetheindustrializationofbioengineering..
Familymember
Whenhewasachild,hewasinfluencedbyhisgrandparents’technicalbackgroundinengineeringandmedicine,andheformedahobbyofscienceandtechnology.TheonlyimpressionhehadmetwashisgrandmotherYuwhenhewas4yearsold.Hisfatherwasamilitiabattalioncommander.Inthe1950s,hecametoGutaishanfromtheOrganizationDepartmentoftheCountyPartyCommitteetoestablishastate-ownedforestfarmandmedicinalplantingbase.Whatimpressedmemostwasin1972and1976.Asaprimaryschoolstudent,healsointuitivelyfeltthatitwasstrangetocriticizeancientConfuciustogether,whichledtotheformationofapathtoexplorethespiritofscienceandethicsbeforegraduatingfromuniversity.
Hewasmarriedin1987.HiswifewasborninChangsha,Hunanin1963.HegraduatedfromtheDepartmentofChemistryatEastChinaNormalUniversityinShanghai.Hehasadaughter.HiswifeanddaughterstudytogetherinIsrael,GermanyandtheUnitedKingdom.
Inthememoryofhisgrandmotherandfather,especiallythetraditionalsacrificesofhisfatherathome,afterhecametoIsrael,hediscoveredthehistoricaloriginofChinese-Jewish,Indian-Greekcultureandancientcustoms;,Iamconvincedthatthenormaldevelopmentofsocietymusthavethedualmanagementoflaw,system,ethics,andbelief,sothatpeople'sthoughtsandbehaviorsareobsessedwithsocialprogress,scienceandtechnology,andcreativeinventions.Humanliberationistheliberationofcreativity.ThefirstthinghedidwhenhereturnedfromEuropewastogotoQufuinShandong,SuzhouinJiangsu,HuizhouinAnhuiandJi'aninJiangxitofindthefootprintsofhisancestors.
IndustrialThoughts
ThefinancialcrisistriggeredbytheUnitedStateshasspreadtotheworld.Itisbothacrisisandanopportunity.Thetransformationofindustrialmodelorindustrialstructureisoftenafeatureoftheneweconomyandnewindustryera,andtechnologicalrevolutionhasbroughtaboutindustrialrevolution.SincethefirstindustrialrevolutionstartedintheMidwestofEngland,andthesecondindustrialrevolutionoccurredinEuropeandAmericaalmostatthesametime,theformationofsocialindustrialstructureandeconomicgrowthhavedevelopedintoanewhistoricalperiod.
IntheMingandQingdynastiesofChina,industriessuchastextiles,printinganddyeing,andmininghavesprouted.ShanximerchantsandHuizhoumerchantsformedwell-knownbusinessmodelsatthenorthernandsouthernendsoftheSilkRoad.ThedevelopmentofmodernscienceintheWestcanseesomefactorsinChineseculture,suchasConfuciansocialethics(scientificsocialnorms),Mohistpracticeexperience(experimentaltechniques),andZenclarification(theoreticalthinkingepiphany))AndTaoistsystemlogicmodel(holographicstructuremodel),aswellasprototypesofsometechnologicalinventions.China’smodernindustrializationhasexperiencedJiangnanmanufacturingintheeraofZengGuofanandShengXuanhuai,andtheeraofspecialeconomiczonesinGuangdongandFujian.IthasbeguntodevelopfromthePearlRiverDelta,YangtzeRiverDeltaandBohaiBaytothecentralandwesternregions.Theessenceofeconomicgrowthistechnologicalinnovationandindustrialization,whichisreflectedinthesocialvitalityofinventors,entrepreneursandfinanciers.Aimingatthenewtechnologicalrevolutionandseizingtheentireeconomicchainfromtechnologicalcreativitytoproductmarketizationinatimelymannerwillbringopportunitiesfortheeconomytorisefromthefoundation.
Thescientificandtechnologicalmethodologyofthe20thcenturytransformedfromempiricalanalysistosystemintegration.Thedevelopmentofartificialintelligenceandmicroelectronicstechnologyledtotherevolutionofinformationindustriessuchascomputersandtelecommunications,andbroughtthedevelopmentofgenomeprojectsandbioinformatics.Syntheticphilosophywasformedlongbeforethebirthofsystemscience,Spencer'ssyntheticphilosophy,Russell'sphilosophicalanalysisandsynthesis,andWhitehead'sorganicphilosophybeforethe19thandearly20thcenturies.Inthelate1980sandearly1990s,theChinesePhilosophyofSciencesessiondiscussedcomprehensivephilosophy,systemsscienceandtraditionalmedicine,andChinesephilosophy.Atthebeginningofthe21stcentury,theworldexplosivelymovedtowardstheintegrationofcomputerscienceandbiologicalsciences,systemsandsyntheticbiology,andtheapplicationofsystemsmedicineandsystemsbioengineering.Intheeraofbio-industrialization,scientificandtechnologicaldecision-makinginstitutionsinEuropeandtheUnitedStateshaveformulatedpoliciesforeducation,scientificresearch,andindustrialreform.ChinahasintroducedmajorprojectsanddecisionstodevelopthemodernizationoftheChinesemedicineindustry.
InJune2007,AcademicianRIKitney,ChairmanoftheDepartmentofBiomedicineandBioengineeringoftheRoyalAcademyofEngineering,said:"Thecouplingofsystemsbiologyandsyntheticbiologywillproducethethirdindustrialrevolution",subvertingThetechnologicalandindustrialchangesinthefieldsofcomputer,nanometer,biologyandmedicinearethebio-industrialrevolution.Theentireindustrialstructureofthe21stcenturywillbetransformedintothe(psychological)bio-(chemical)physicsallianceindustrialmodelofsystematicbioengineering,whichistheintegrationofmaterials,energy,andinformationforecological,genetic,bionicandmechanical,chemical,andelectromagneticengineeringapplications.Industryisembodiedintheprinciplesofbiologicalsystemsofmachines(evolutionarycomputing,geneticcomputing),biomaterials(nanobiomolecules,engineeredbiomaterials),andgeneticallyengineeredorganisms.Computersciencetheoryoriginatesfromtheresearchofanimalcommunicationbehavior,neuralsystemcybernetics,andinformationtheory;italsoexplorestheintracellularandintercellularcommunicationbehavior,whichhasledtothedevelopmentofsystembiologyscienceandengineering,whichwillformthefutureofmaterials,energyandinformationall-roundbiologyindustry.
Thefirstindustrialrevolutionbeganwiththeindustrialscaleofspinningandweavingandthewidespreadapplicationofsteamengines,andendedwiththeinventionoftheinternalcombustionengineandthestartingpointoftheautomobileindustry;thesecondindustrialrevolutionopenedupelectrificationandtelephone,Thedevelopmentoftheelectroniccommunicationindustry,andthecomputerInternettechnologyhasreacheditspeak;thethirdindustrialrevolutionshouldstartfromtheendoforganicchemicalengineering,thebeginningofgeneticengineering,therapiddevelopmentofsystemsbiologyandsyntheticbiology,andthebeginningofthebiologicalindustrialrevolutionThesalientfeatureisinterdisciplinaryandtechnicalintegration.
Integrationofdisciplinesandtechnologiessuchasorganicchemicalsynthesistechnology,high-precisionanalyticalchemistry,nanomolecularscience,microelectronicstechnology,ultra-large-scaleintegration,computersoftwaredesign,geneticallymodifiedbiotechnology,drugscreeninghigh-throughputtechnology,etc.Integrationanddevelopmentofbiomolecularcomputercomponents,artificialintelligencebiocomputing,syntheticcellbiologicalsystems,etc.,willbringabouttheindustrialdevelopmentofartificiallydesignednewbiomolecularmaterials,algaeartificialcellsyntheticpetroleum,andnano-medicalcellrobotsinabout30years.Supportingtheshiftoffocustoplacingfundingonpotentialhigh-techdevelopmentsandinventionswillbethebasisforthedevelopmentoffuturepillarcompanies.
NeedhamQuestion
Firstofall,anycivilizationmodelhasitshistoryorlifeofformation,growth,prosperityanddecline.
Secondly,thegreatinventionsandachievementsoftheChinesecivilizationfrom500to1500ADaretheformofagriculturalcivilization;EuropeatthistimeisthedarkageoftheintegrationofpoliticsandreligionintheMiddleAges,whichburneddownGreekandRomanclassics.
Thirdly,theArabEmpireactedasabridgefortheintegrationofEasternandWesterncultures-preservedGreekandRomanculturalclassics,disseminatedChineseandChinesescienceandtechnology(pre-science)-translatedintoArabicandthentranslatedintoLatin.
Fourth,theSilkRoadandMarcoPolohaveinfluencedColumbustoopenupEurope’snewEasternrouteandtheRenaissance,andtheformationofsecularuniversitiesandintellectualgroupsinEurope.
Fifth,modernscienceandtechnologyandtheindustrialcivilizationmodelarethefusionofEasternandWesterncultures.ThemethodologyofmodernexperimentalscienceisdifferentfromtheformallogicofancientGreece.RogerBaconwasborninthecombinationofalchemyandalchemy.Medicalchemistryandexperimentalmethods;thecombinationofChineseandWesternmedicinebringstheparadigmofpsychosomaticmedicineandsystemscience,whichconstitutesatwo-dimensionalscienceofexperimentandsystemmethods.
Fifth,ConfucianismhasaveryimportantinfluenceonEuropeanhumanismandtheestablishmentofacivilservicesystem.Confucianists(bothpoliticalandintellectual)enterofficialcareersandthesystemofseparationofpoliticsandreligion.
Seventh,EuropeexpandedfromEasternEurope,SouthernEurope,andNorthernEuropetothePacificRim.EasternandWesternculturesonceagainmergedtoformthefourthtechnologicalrevolutioninsystemsbiologyandengineering,andtheriseofConfucianmerchants.
Eighth,ChinadidnotorcouldnotrecognizethevalueofancientGreekandRomancivilizationsandlearnanddigestthemduringtheperiodofgreatprosperity.
Ninth,averyimportantthinginmodernEuropeisthereligiousreform(MaxWeber’sProtestantethicsandthespiritofcapitalism).Confucianreformorneo-ConfucianismisthewayoftheEasternRenaissanceRecordtheimportantfunctionsofConfucianethicsinsocialmanagement).
Tenth,Confucianismdoesnothaveidolatryatall,andZenalsoregardsenlightenmentasitssect.TheendofMingandQingdynastiesledtoidolatryandtheclosureofthesystem.
Theeleventh,theeducationsystemandabilitytrainingofcreativespirit,modeandmethodisthekey.Specificknowledgeandtechnologyarealwaysemerging.Itisnotalwayspossibletotracklearningtechnologyandknowledge,buttocultivateinnovativeandpioneeringtalents..
Secondly,thesustainabledevelopmentoftechnologyandeconomyrequiresvarioustypesoftalentssuchasinvention,innovation,practiceandskill.Modernindustrializationisbasedontheintellectualpropertyrightsofentrepreneurswhoaretechnologicallyinvented.Basedonthesystem,integrity,dedication,teamworkandinnovationarethefoundationsofsocialcareerdevelopment.
OriginalContributions
Thecorecontentofthe1991-1999systemicbiologicalsciences:
1)Structuraltheoryofbiologicalsystems;
2)Researchonbiologicalsystemsintegratingexperimentalandcomputationalmethods;
3)Systematicscientificresearchoncellsignaltransductionandgeneregulatorynetworks;
4)ArtificialintegrationofbioengineeringandbionicsBiologicalsystemdevelopment,etc.,includingcoinedtermssuchas"systemgenetics","systemsmedicine","systemsbioengineering"and"oviductbioreactor".
Pan-evolutionarystructuraltheory
From1983to1986,theecologicaladaptationandotherreferencesystems,thetopologicalanalysisofbiologicalevolutionandmorphogenesis,foundthelimitationsofDarwin'stheoryofevolution,andformedthebiologicalsystem.Thestructuraltheoryofpan-evolutionarysystems.The1992-1993NationalConferenceandtheInternationalConferencesince1993discussedtheconceptsofbiologicalsystems,geneticinformation,structuralintegration,adaptivehomeostasisandconstructionsynthesis,andsystematicanalysisandsynthesisofthewholetothecomponent,thecomponenttothewhole,andthestructureandfunctionconversion.Themethodconstitutesthestructuraltheoreticalbasisofsystemsbiologyandsyntheticbiology.
SystemBioengineering
In1991,hepublishedascientificexperimentandsystemmethodfortheintegrationofChineseandWesterncultures,andputforwardtheconceptofsolar-bioelectronictechnologyintegratingsystemscience,artificialintelligence,andgeneticengineering.Discusstheintegrationofcomputertechnologyandbiotechnology.In1994,hepublishedthecategoryandprincipleofsystembioengineering,andtheconceptandsystemschemeofconstructingtransgenicpoultryoviductbioreactorusingflankingsequenceofeggwhiteproteingene.Atthebeginningof1999,theSystemBiologyScienceandEngineeringNetwork(Oct.14,NatureandDecemberKybernetes,etc.)wasestablished.In2002,acellcomputermodelartificiallydesignedforgeneregulation,signaltransductionandenergyconvertersofthecellcommunicationsystemwasproposed.
SystemsMedicine
In1992,thefirstNationalSymposiumonComparisonofTraditionalChineseandWesternMedicineexplainedthatthefutureofthedevelopmentofChineseandWesternmedicineistowardssystemicmedicine,andproposedtheneuro-endocrineandimmunefunctionsofsystemicmedicine.Thefunctionallyintegratedmeridiansystemandthefunctionalhomeostasisstructuremodelofthemetabolicandcirculatoryorgansystems,etc.From1992to1994,heproposedtherhythmandschematransformationmodelofneurologicalandgenebidirectionalregulationofdevelopmentatthemolecularcelllevel.In1995,hepublishedtheprinciplesandmethodologyofsystematicsciencefromempiricaltocomprehensivedevelopmentofmedicalscience.
Systemgenetics
Genome-phenotypecomplexsystemtransitionandnonlinearcellgenerationdynamicscorrespondingtogenomestructureandorganismschema,1994-2003systembiotechnologywasdevelopedResearch,establishedatypicalexperimentandsequencemarkerfragmentdisplayanalysisofcontinuouscellmutationandscreening.Duetotheproblemsofdiseasemodelsandtransgenes,publishedin1994theregulatorystructureofgenometoenzymesystem,organmorphology,andtheconceptofsystemgenetics,andproposedthedevelopmentfromclassical,moleculartosystemgenetics,the1stInternationalAcademicSeminaronTransgenicAnimalsin1996Lecturesonbiologicalsystemtheoryandgeneticswerepresentedatthemeeting,andtheywerere-discussedatthe2003InternationalCongressofGenetics.
(1983-2003)
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